A screening of TNF-α inhibition activity by cyclopropylmethylphosphonate

Abstract

TNF-α is a member of a family of proteins called cytokines that are important components of the immune system. Their physiological role in inflammation is well recognized. An imbalance in their production contributes to various pathological disorders. Encouraged by our previous TNF-α result, four cyclopropylmethylphosphonate 2 compounds which were synthesized using 1-alkynylphosphonates 1 with the reagent system Cp₂ZrCl₂/2EtMgBr/2AlCl₃ and were found to be active as TNF-α inhibitors.