A Comprehensive Review of Therapeutic Potentialof Nanobodies

Abstract

 Recently, nanobodies have taken center stage in drug discovery and development research. Several nanobodies therapeutic possibilities are undergoing clinical trials and waiting for the Food and Drug Administration’s approval. This study aimed to emphasize the potential of nanobodies as therapeutic agents by concentrating on the most recent published studies that examined their properties, manufacturing, and possible applications. This article demonstrates that the unique properties of nanobodies, compared to conventional antibodies, which are based on their small size and offer a number of benefits, make them seem to have a promising future. These advantages include accessing complex or hidden target sites that may be elusive to their larger antibody counterparts and increased resilience against extreme conditions like temperature changes and pH variations. As a result, nanobodies seem to have a bright future as adaptable tools for imaging in cancer and non-malignant diseases, as well as for in vitro and in vivo diagnostic and therapeutic potential for a variety of conditions, including oncology, infectious, metabolic, neurological, and other conditions like ophthalmologic, immune-mediated, and genetic disorders. More research is required to determine their effectiveness and safety in clinical applications. The current analysis offers a thorough overview of the therapeutic uses for nanobody
products that are either on the market or undergoing clinical trials.